Start Submission Become a Reviewer

Reading: Evaluation of the Efficacy of Propofol-Magnesium Sulfate Combination for Sedation in Paediat...

Download

A- A+
Alt. Display

Research article

Evaluation of the Efficacy of Propofol-Magnesium Sulfate Combination for Sedation in Paediatric Magnetic Resonance Imaging of Brain.- a Randomized Controlled Trial

Authors:

Prashant Atmaram Lomate,

Bharati Vidyapeeth (deemed to be university) medical college and hospital, Sangli, IN
X close

ganesh mallappa kumbhar ,

Bharati Vidyapeeth (deemed to be university) medical college and hospital, Sangli, IN
X close

jyotsna satish paranjpe

Bharati Vidyapeeth (deemed to be university) medical college and hospital, Sangli, IN
X close

Abstract

Background and Aims: The key to successful sedation for paediatric magnetic resonance imaging (MRI) is to keep the child completely immobile while at the same time to ensure rapid recovery and minimal airway intervention. We compared the efficacy of propofol-midazolam and propofol-magnesium sulfate sedation for paediatric MRI of the brain. Methods: A total of 60 paediatric patients, aged 1 to 8 years posted for MRI brain were randomly allocated into two groups. Group I patients received midazolam 0.05mg/kg and Group II patients received magnesium sulfate 30 mg/kg intravenous infusion in the preinduction room. In the MRI room all patients were sedated with 1-2 mg/kg bolus and 100 ug/kg/min infusion of propofol. The two groups were compared for sedation characteristics like induction time, discharge time, awakening time, total number of additional propofol boluses, agitation scores, scan quality, haemodynamic parameters and adverse events. Fisher exact test was used for all quantitative data. Results: The discharge time was shorter in Group II (41.03 ± 8.39 min versus 32.83 ± 5.97 min;P<0.001). Induction time, awakening time, scan quality and requirement of additional propofol boluses were comparable for the groups (P>0.05). Incidence of emergence agitation was significantly lower in Group II (P<0.01). Heart rate remained on lower normal side, 20 minutes after induction in Group II (P<0.00). There was no statistically significant incidence of airway instrumentation between both groups (p=0.14). Conclusion: Propofol-magnesium sulfate sedation is a better alternative to propofol-midazolam combination for paediatric brain MRI, as it provided shorter discharge time and lower incidence of emergence agitation.
How to Cite: Lomate, P.A., kumbhar, . ganesh . mallappa . and paranjpe, . jyotsna . satish ., 2022. Evaluation of the Efficacy of Propofol-Magnesium Sulfate Combination for Sedation in Paediatric Magnetic Resonance Imaging of Brain.- a Randomized Controlled Trial. Sri Lankan Journal of Anaesthesiology, 30(1), pp.46–51. DOI: http://doi.org/10.4038/slja.v30i1.8873
Published on 11 Jun 2022.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus