Acquired neuromuscular disorder due to critical illness polyneuropathy (CIP) develops in patients admitted to intensive care unit for more than one week. CIP could present with weakness and delayed weaning from mechanical ventilation. It is often diagnosed on clinical suspicion and confirmed with electro-physiological studies. Severe sepsis and multi-organ failure are important risk factors and impaired glycaemic control contributes to CIP1. CIP results in prolonged mechanical ventilation, prolonged rehabilitation and increased morbidity and mortality.