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Reading: Epidural levobupivacaine with clonidine prolongs anaesthesia and analgesia

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Clinical Investigations

Epidural levobupivacaine with clonidine prolongs anaesthesia and analgesia

Authors:

Arunkumar Arumugam ,

sir ganga ram hospital, IN
About Arunkumar
Senior resident, Department of cardiac anaesthesia, Sri Ganga Ram hospital, New Delhi-110060
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Neelima Tandon,

Gajra Raja Medical College, IN
About Neelima
Associate Professor, Deaprtment of Anesthesiology, Gajra Raja Medical College, Gwalior, M.P
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Bhanu Choudhary

Gajra Raja Medical College, IN
About Bhanu
Professor and Head, Department of Anesthesiology,Gajra Raja Medical College, Gwalior, M.P
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Abstract

Background: Epidural anaesthesia is a safe alternative for general anaesthesia in patients undergoing infraumbilical surgeries. This study was conducted to evaluate the effect of clonidine as an adjuvant to levobupivacaine, an S (-) enantiomer of bupivacaine.

 

Material and Methods: Hundred patients of ASA grade I and II undergoing infraumbilical surgeries were randomized in two groups as L and LC. Group L received 0.5% levobupivacaine (1.5mg/kg) and group LC received 0.5% levobupivacaine (1.5mg/kg) with clonidine (2µg/kg). The onset time for sensory, motor blockade, duration of anaesthesia and duration of analgesia, VAS score were observed in both the groups. The haemodynamic variables such as heart rate, systolic and diastolic blood pressure, respiratory rate and SPO2 at various time intervals were measured. Any untoward side effects were noted in both groups.

 

Results: The onset of sensory (7.8±1.7mins) and motor blockade (10.9±1.9mins) was significantly faster in clonidine group. Duration of anaesthesia and duration of analgesia was prolonged in group LC (234.5±16.1mins, 412.8±48.3mins) compared to group L (173.56±12.78 min, 269.2±24.2mins) which was statistically significant (p<0.05). Similarly clonidine group had less VAS score compared to control group. There was no significant change in the haemodynamic variables between the two groups. Hypotension and bradycardia was found more in clonidine group compared to the control group.

 

Conclusion: Clonidine as an adjuvant to levobupivacaine prolongs the post-operative analgesia and the duration of anaesthesia for infraumbilical surgeries.

DOI: http://doi.org/10.4038/slja.v24i2.8126
How to Cite: Arumugam, A., Tandon, N. & Choudhary, B., (2016). Epidural levobupivacaine with clonidine prolongs anaesthesia and analgesia. Sri Lankan Journal of Anaesthesiology. 24(2), pp.70–75. DOI: http://doi.org/10.4038/slja.v24i2.8126
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Published on 16 Jul 2016.
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