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Efficacy of analgesic effect of low dose intrathecal clonidine as adjuvant to bupivacaine in urogenital surgeries: study in a Kashmiri population

Authors:

Zahoor Ahmad Shah,

Assistant Professor, Dept. of Anesthesiology & Critical Care, SKIMS, Srinagar, Jammu & Kashmir, IN
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Raksha Kundal,

Resident, Dept. of Anesthesiology & Critical Care, SKIMS, Srinagar, Jammu & Kashmir, IN
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Arun Kumar Gupta ,

Assistant Professor, Dept. of Anesthesiology & Critical Care, SKIMS, Srinagar, Jammu & Kashmir, IN
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Mohd Sadiq Malla,

Senior Resident, Dept. of Anesthesiology & Critical Care, SKIMS, Srinagar, Jammu & Kashmir, IN
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Faisal Zahoor,

Resident5, Dept. of Emergency Medicine, Apollo Hospital, New Delhi, IN
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Vijay Kundal,

Senior Resident, Dept. of Paediatric Surgery, SMS Hospital, Jaipur, IN
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Sameena Ashraf Kirmani,

Resident, Dept. of Anesthesiology & Critical Care, SKIMS, Srinagar, Jammu & Kashmir, IN
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Shigufta Qazi

Professor & Head, Dept. of Anesthesiology & Critical Care, SKIMS, Srinagar, Jammu & Kashmir, IN
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Abstract

Background: Previous studies have shown that clonidine given intrathecally in higher doses cause side effects. In this study, we used low dose clonidine intrathecally (1 μg /kg) as adjuvant to bupivacaine to study efficacy of analgesia and side effects.

Method: 60 patients were randomly divided into two groups of 30 patients each. They were aged 20 to 60 years, of ASA Class I and II undergoing genitourinary surgeries. The clonidine group (A) received 1 μg/kg clonidine in addition to bupivacaine 12.5mg (0.5%) and control group (B) received an identical volume of saline mixed with 12.5mg (0.5%) bupivacaine. Efficacy of spinal analgesia was compared between these two groups.

Results: Duration of analgesia, motor block, highest level of sensory block and time taken for regression of sensory analgesia by two segments was more in the clonidine group. There was a reduction in heart rate and systolic blood pressure which was statistically insignificant. Side effects like nausea and sedation were insignificant.

Conclusion: Addition of low dose clonidine (1μg/kg) to bupivacaine increases the duration of spinal analgesia as compared to bupivacaine alone with clinically insignificant influence on haemodynamic parameters and level of sedation.

DOI: http://dx.doi.org/10.4038/slja.v20i1.3072   

Sri Lankan Journal of Anaesthesiology 20(1): 49-52 (2012)     

DOI: http://doi.org/10.4038/slja.v20i1.3072
How to Cite: Shah, Z.A. et al., (2012). Efficacy of analgesic effect of low dose intrathecal clonidine as adjuvant to bupivacaine in urogenital surgeries: study in a Kashmiri population. Sri Lankan Journal of Anaesthesiology. 20(1), pp.49–52. DOI: http://doi.org/10.4038/slja.v20i1.3072
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Published on 21 Apr 2012.
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